Buy Zycan

$70.00

Zycan is a semi-synthetic polysulfated glycosaminoglycan (PSGAG) and is physiologically similar to the natural mucopolysaccharides found in joint cartilage. The low molecular weight of Zycan facilitates the distribution of the PSGAG from the bloodstream to the synovial fluid. Distribution from the synovial fluid to the cartilage then takes place by diffusion. PSGAG is deposited in all layers of articular cartilage and is preferentially taken up by osteoarthritic cartilage. When administered intramuscularly, synovial levels exceed serum levels, peak in 48 hours and persist for up to 96 hours. The latter is the rationale behind every fourth day dosing. PSGAGs exert their chondroprotective effects by inhibiting the detrimental effects of cytokines and PG’s on cartilage and connective tissue, reducing proteoglycan breakdown, stimulating HA synthesis and enhancing the production of glycosaminoglycan, proteoglycan and collagen. In multiple studies, PSGAGs have been shown to: • Inhibit various degradative proteolytic enzymes, including glycanohydrolases, glycosidases and MMPs. • Inhibit MMP-3 more effectively than phenylbutazone, flunixin, betamethasone and HA. • Increase collagen and GAG synthesis in articular cartilage explants and cell culture.

Category: Tag: